This quote from paleoanthropologist John Hawks is kind of intriguing:
You know, it seems to me that the best science fiction gets one science concept really right, even if it leads to results that seem unrealistic.
My favorite along these lines is a classic, Cyril Kornbluth's "The Marching Morons." It's the original version of "Idiocracy" — the basic idea is that selection now favors the stupid, and so if we go forward in time, that's what we'll see. The concept is simple and well-drawn; the consequences unexpected.