I like the Ruger LC9s and the LC9s Pro, (the latter lacks a thumb safety and a magazine disconnect safety). A great little striker-fired pocket pistol that is light, easy to shoot and accurate. This is a gun I carry for basic self-defense.
On the other hand, when I want to be absolutely sure of blowing an assailant's head clean off, I carry a Ruger Redhawk chambered in .41 Magnum, demonstrated here by Jeff Quinn (who is not only a knowledgeable gun guy, but he also has a truly cool beard).
For those interested in the .41 Magnum round, here's the entertaining Hickok45 blasting away with a S&W Model 57.